ArticleSexually transmitted diseases2026
Susceptibility to Penicillin G and Ceftriaxone in 3 Clinical Treponema pallidum Isolates Is Not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein.
Article in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026Review
- The Global Syphilis Epidemic: Turning the Tide.Sexually transmitted diseases · 2026Article
- A New Era in Treponema pallidum Cultivation: Current Advances and Future Directions.Sexually transmitted diseases · 2026Review
Corrections and comments
- Update of
Authors and funding
5 authors.
Funding
Abstract
We demonstrated no differences in susceptibility to penicillin G and ceftriaxone in 3 modern Treponema pallidum isolates (UW244B, UW249B, and UW330B), each carrying a variant of the penicillin-binding protein Tp0705. This suggests that these polymorphisms should not be a reason for concern when β-lactams are prescribed for syphilis treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.