Evidence map›Paper›PMID 41439714›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Early activation of bioenergetic metabolism powers bacterial spore germination.

Pooja Gupta, Rebecca Caldbeck, Rowan C Walters, Elodie C Wells, Bethany L Hardman, Graham Christie, Roger J Springett, James N Blaza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effect of Ammonia onAntioxidants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pooja GuptaYork Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0002-0944-4498
Rebecca CaldbeckDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.ORCID 0009-0007-7380-2660
Rowan C WaltersYork Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0002-1067-8494
Elodie C WellsYork Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.ORCID 0009-0008-2532-6118
Bethany L HardmanYork Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.
Graham ChristieDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.
Roger J SpringettYork Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.
James N BlazaYork Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, United Kingdom.ORCID 0000-0001-5420-2116

Funding

UK Research and Innovation (UKRI) MR/T040742/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X003035/1
6 · The paper itself

Abstract

Dormant bacterial spores germinate to become vegetative cells upon germinant exposure. Despite many germinants being energy sources, bioenergetic processes have been overlooked as germination can proceed, albeit slowly, without exogenous energy sources. Here, we apply remission spectroscopy to noninvasively measure energization of the electron transport chain (ETC) in germinating spores. In

Indexed as

Bacillus megateriumBacillus subtilisEnergy MetabolismSpores, BacterialBacterial ProteinsElectron TransportModels, BiologicalOxidoreductasesBacterial ProteinsOxidoreductasesbioenergeticscytochromegerminationspectroscopyspore

Identifiers

PMID41439714
PMCPMC12772218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.