ReviewJournal of cosmetic dermatology2026
An Innovative Formula for Keratosis Pilaris Treatment-A Randomized Controlled Study Based on the "Exfoliation-Dissolution-Repair" Concept.
Review in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- An Innovative Formula for Keratosis Pilaris Treatment-A Randomized Controlled Study Based on the "Exfoliation-Dissolution-Repair" Concept.Journal of cosmetic dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveKeratosis pilaris (KP) is a common follicular keratotic skin disorder characterized by follicular papules and skin roughness, often accompanied by itching and inflammation, significantly affecting appearance and psychological health.
methodsThis 28-day prospective, open-label, randomized controlled study evaluated the effectiveness of a novel combined formula for KP treatment. The formula included a scrub (Olea europaea shell powder, hydrated silica, and papain) and a moisturizing lotion with plant oils (peony seed oil, oat kernel oil, and rice bran oil). Sixty KP patients aged 18-35 were randomly assigned to a control group (salicylic acid body lotion) or a study group (combined formula), with 30 participants each. Evaluations included follicular papule counts, transepidermal water loss (TEWL), and depression scale scores at baseline (D0), day 7 (D7), day 14 (D14), day 21 (D21), and day 28 (D28). After D28, a self-assessment questionnaire was used to compare treatment outcomes.
resultsAccording to the repeated-measures ANOVA, the control and study group had a significant reduction in follicular papule counts over time (all p < 0.05). For TEWL values, a significant simple effect of time was observed in the study group (p = 0.026), whereas the control group showed only a marginal change (p = 0.054). Despite the absence of a significant main group effect (p = 0.287), these results suggest that the study group achieved a greater overall improvement in skin barrier function over time. In the self-assessment, 21 out of 23 indicators had higher effectiveness rates in the study group than the control group, with 96.7% effectiveness in improving skin dryness, smoothness, roughness, freshness, oiliness, and oil control. Depression scale scores were significantly affected by both time and group (p = 0.017 and p = 0.008, respectively), indicating psychological improvement after 28 days.
conclusionThe combined formula effectively reduced follicular papules, improved skin hydration, decreased TEWL, and alleviated depressive symptoms in KP patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.