Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2026
Predictors of Quit Attempts and Successful Smoking Abstinence in Pregnancy: An Exploratory Analysis of a Pooled Clinical Trial Dataset.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionSmoking in pregnancy is a preventable cause of detrimental effects on mother and baby, exacerbating socioeconomic health disparities. This study investigates predictors of making a quit attempt and smoking abstinence in pregnancy.
methodsThis study used pooled data from two large UK multicenter smoking cessation intervention trials in pregnancy (N = 1409). Baseline predictor variables included demographic, smoking behavior, and quitting belief measures. Percentage of cigarettes cut down in early pregnancy was a novel variable. Outcomes (36 weeks' gestation) were having made a quit attempt (>24 hours) and smoking abstinence (both self-reported). Exploratory logistic regression analyses, with missing smoking outcomes imputed as non-abstinent, involved univariate then multivariable analyses. Sensitivity analyses included complete case analyses and biochemically validated abstinence.
resultsA total of 1409 women were included in study analyses. In multivariable analyses, for making a quit attempt, higher intention to quit (OR = 1.50, 95% CI = 1.26% to 1.79%) and higher combined self-efficacy score (OR = 1.60, 95% CI = 1.30% to 1.96%) were statistically significant predictors. For smoking abstinence, higher percentage reduction in number of cigarettes smoked in early pregnancy (OR = 1.02, 95% CI = 1.01% to 1.02%) and longer previous quit attempt (omnibus p = .001) were statistically significant predictors.
conclusionsSmoking beliefs, including motivational factors, were statistically significant predictors of making a quit attempt. However, smoking behaviors relating to cutting down the number of cigarettes in early pregnancy and having had a previous period of smoking abstinence >6 weeks were predictors of successful smoking abstinence. IMPLICATIONS: This study adds to the evidence that motivational factors are important in initiating a quit attempt, whereas positive behavioral changes are associated with smoking abstinence in pregnant women. This information could be used by clinicians designing smoking abstinence support for pregnant women. Women who reduce the number of cigarettes they smoke very early in pregnancy might be more receptive to smoking abstinence support offered at that point.
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