Evidence map›Paper›PMID 41439508›Full record

ArticleeLife2025

Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection.

Alina Xiaoyu Yang, Lisa Ramos-Rodriguez, Parand Sorkhdini, Dongqin Yang, Carmelissa Norbrun, Sonoor Majid, Sanghyun Lee, Yong Zhang, Michael Holtzman, David F Boyd and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Phospholipid scramblase 1: a frontline defense against viral infections.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alina Xiaoyu YangDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.ORCID https://orcid.org/0000-0003-1528-9129
Lisa Ramos-RodriguezDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.
Parand SorkhdiniDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.
Dongqin YangDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.
Carmelissa NorbrunDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.
Sonoor MajidDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.
Sanghyun LeeDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.
Yong ZhangDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine in St. Louis, St. Louis, United States.
Michael HoltzmanDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine in St. Louis, St. Louis, United States.
David F BoydDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, United States.
Yang ZhouDepartment of Molecular Microbiology and Immunology, Brown University, Providence, United States.ORCID https://orcid.org/0000-0001-6867-6443

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI KOGUT, STEPHEN J · 2016 to 2025
$45.0M
Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Defining and Controlling Airway DiseaseR35HL145242 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2019 to 2025
$6.6M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Targeting CHI3L and its receptors in Hermansky-Pudlak Syndrome-associated lung diseaseR01HL146498 · NHLBI · BROWN UNIVERSITY · PI ZHOU, YANG · 2020 to 2024
$2.2M
Viral immune evasion during intestinal norovirus infectionR01AI183155 · NIAID · BROWN UNIVERSITY · PI Sanghyun Lee · 2024 to 2026
$1.7M
American Heart Association 10.58275/aha.24tpa1277918.pc.gr.196624American Heart Association-American Stroke Association 24TPA1277918American Thoracic Society 23-24PHP11NHLBI NIH HHS R01 HL146498NHLBI NIH HHS R35 HL145242NHLBI NIH HHS T32 HL134625NIAID NIH HHS R01 AI183155NIGMS NIH HHS P20 GM103652NIGMS NIH HHS U54 GM115677
6 · The paper itself

Abstract

Phospholipid scramblase 1 (PLSCR1) is an interferon-stimulated gene (ISG) that has several known anti-influenza functions. However, the mechanisms in relation to its expression compartment and enzymatic activity have not been completely explored. Moreover, only limited animal models have been studied to delineate its role at the tissue level in influenza infections. Our results showed that influenza A virus (IAV)-infected

Indexed as

Influenza A virusInterferonsOrthomyxoviridae InfectionsPhospholipid Transfer ProteinsReceptors, InterferonSignal TransductionAnimalsHumansMiceMice, Inbred C57BLMice, KnockoutIFNLR1 protein, mouseInterferonsPhospholipid Transfer ProteinsReceptors, InterferonIFN-λimmunologyinfectious diseaseinflammationinfluenza A virusmicrobiologymousePLSCR1

Identifiers

PMID41439508
PMCPMC12736948

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.