Evidence map›Paper›PMID 41439497›Full record

Trial reportJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2026

Effects of Ozonized Oil on At-Home Tooth Bleaching: A Double-Blind Randomized Clinical Trial.

Murilo Guimarães Campolina, Lia Dietrich, Julia Marques Martins, Larissa Victoria Miranda Ubagai, Guilherme José Pimentel Lopes Oliveira, Ceci Nunes Carvalho, Hugo Lemes Carlo, Carlos José Soares, Gisele Rodrigues Silva

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Murilo Guimarães CampolinaDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-6079-8718
Lia DietrichDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of dos Vales Do Jequitinhonha e Mucuri, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-7887-8591
Julia Marques MartinsDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-5870-2342
Larissa Victoria Miranda UbagaiDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0009-0006-1769-8056
Guilherme José Pimentel Lopes OliveiraDepartment of Periodontology & Oral Implantology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-8778-0115
Ceci Nunes CarvalhoDental School, CEUMA University, Maranhão, Brazil.ORCID https://orcid.org/0000-0002-1706-4081
Hugo Lemes CarloDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-5111-7781
Carlos José SoaresDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-8830-605X
Gisele Rodrigues SilvaDepartment of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-9358-1339

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 406840/2022-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Financial Code 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02621-21Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00204-23
6 · The paper itself

Abstract

objectiveThis double-blind, randomized clinical trial evaluated the effect of ozonized sunflower oil on tooth sensitivity, color change, and patient perception during at-home bleaching with 10% hydrogen peroxide. CLINICAL CONSIDERATIONS: Forty participants were randomly assigned to receive ozonized or nonozonized sunflower oil, applied in trays for 1 min after each bleaching session (30 min daily for 21 days). Sensitivity was assessed daily using visual and numerical scales. Tooth color was measured at baseline, 1 week, and 1 month after treatment using a spectrophotometer (ΔEab, ΔE00, ΔWID) and a visual shade guide (ΔSGUs). Patient perception was evaluated through Likert-scale questionnaires.

conclusionsOverall, 72.5% of participants experienced sensitivity, with no significant difference in intensity (p = 0.536) or duration (p = 0.256) between groups. Color changes were similar (p > 0.05), although ΔEab and ΔE00 values decreased at 1 month (p = 0.010 and p = 0.026). Ozonized oil had an unpleasant taste (p = 0.002) and odor (p = 0.010). The use of ozonized sunflower oil did not reduce bleaching-related sensitivity or enhance whitening effectiveness, and its poor sensory properties may limit patient acceptance.

Indexed as

Dentin SensitivityOzoneSunflower OilTooth BleachingTooth Bleaching AgentsAdultDouble-Blind MethodFemaleHumansHydrogen PeroxideMaleMiddle AgedHydrogen PeroxideOzoneSunflower OilTooth Bleaching Agentsdentin desensitizing agentsdentin sensitivityhydrogen peroxideozone therapytooth bleaching

Identifiers

PMID41439497
PMCPMC13069360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.