Evidence map›Paper›PMID 41439483›Full record

ArticleBiochemistry2026

Human TMIGD1 Promoter Exhibits Robust Activity in Prokaryotic Cells.

Rosana Meyer, Kaneyoshi Yamamoto, Bridget Whelpley, Daniel Dempsey, Nader Rahimi

Abstract read
In one paragraph

Article in Biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rosana MeyerDepartment of Pathology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States.
Kaneyoshi YamamotoDepartment of Frontier Bioscience, Hosei University, Koganei, Tokyo 184-8584, Japan.
Bridget WhelpleyDepartment of Pharmacology, Physiology & Biophysics and Department of Dermatology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States.
Daniel DempseyDepartment of Pharmacology, Physiology & Biophysics and Department of Dermatology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States.
Nader RahimiDepartment of Pathology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States.ORCID 0000-0002-6745-1725

Funding

Molecular mechanisms of RNA methyltransferases.R35GM155301 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Daniel R. Dempsey · 2024 to 2026
$1.1M
Training in BioMolecular PharmacologyT32GM159592 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Hui Feng, Venetia Zachariou · 2025 to 2026
$858k
NIGMS NIH HHS R35 GM155301NIGMS NIH HHS T32 GM159592
6 · The paper itself

Abstract

Gene transcription in eukaryotes is orchestrated by intricate regulatory architectures that depend on chromatin context and a diverse repertoire of transcription factors. Consequently, eukaryotic promoters are thought to be incompatible with the streamlined transcriptional machinery of bacteria. Here, we challenge this assumption by demonstrating that a minimal 90-bp fragment of the human TMIGD1 promoter functions as an active, constitutive promoter in

Indexed as

Escherichia coliMembrane ProteinsProkaryotic CellsPromoter Regions, GeneticHumansTranscription, GeneticMembrane Proteins

Identifiers

PMID41439483
PMCPMC12933629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.