Evidence map›Paper›PMID 41439463›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2026

A Study on the Characteristics of Sonazoid Contrast-Enhanced Ultrasound in the Transitional Phase for Common Focal Liver Lesions and Its Value in Differential Diagnosis.

Yunhao Luo, Danlin Wen, Jing Zhang, Zhengrong Song, Yang Liu, Yan Liu, Qiang Mao, Yunquan Zhou, Liwen Ma, Congcong Yu and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
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Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yunhao LuoSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0009-0005-5984-7286
Danlin WenDepartment of Ultrasound, Sichuan Integrative Medicine Hospital, Chengdu, China.ORCID https://orcid.org/0000-0002-8048-4409
Jing ZhangDepartment of Ultrasound, The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, China.ORCID https://orcid.org/0000-0002-7803-2075
Zhengrong SongFunctional Examination Department, Pengzhou Hospital of Traditional Chinese Medicine, Chengdu, China.ORCID https://orcid.org/0009-0007-8046-3169
Yang LiuDepartment of Ultrasound, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China.ORCID https://orcid.org/0009-0008-5751-0569
Yan LiuDepartment of Ultrasound, Affiliated Hospital of Panzhihua University, Panzhihua, China.ORCID https://orcid.org/0000-0002-4191-7400
Qiang MaoDepartment of Ultrasound Medicine, Second People's Hospital of Yibin, Yibin, China.ORCID https://orcid.org/0009-0000-1911-0187
Yunquan ZhouUltrasound Medicine Department, Chengdu Fifth People's Hospital, Chengdu, China.ORCID https://orcid.org/0009-0002-0786-7769
Liwen MaDepartment of Ultrasonic Medicine, Chengdu Wenjiang District People's Hospital, Chengdu, China.ORCID https://orcid.org/0000-0003-4547-3138
Congcong YuSub-Health Clinical Detection and Evaluation Laboratory, Chengdu, China.ORCID https://orcid.org/0000-0002-3831-0819
Lang QiaoDepartment of Ultrasound, Sichuan Integrative Medicine Hospital, Chengdu, China.ORCID https://orcid.org/0009-0008-0837-9963

Funding

Sichuan Medical Science and Technology Innovation Research Association Research Project YCH-ZZ2023-021Sichuan Provincial Department of Science and Technology Research Project 2024NSFSC0725
6 · The paper itself

Abstract

objectiveTo investigate the value of transitional phase characteristics on Sonazoid contrast-enhanced ultrasound (S-CEUS) in the differential diagnosis of common focal liver lesions (FLLs). MATERIALS AND

methodsThis prospective multicenter study enrolled 122 participants with FLLs from 8 medical centers between December 2023 and March 2025. The study comprised 43 cases of hepatic hemangioma (HH), 35 cases of hepatocellular carcinoma (HCC), and 44 cases of liver metastases (LM). All participants underwent standardized S-CEUS examinations. The enhancement characteristics and washout patterns during the transitional phase were analyzed for all participants.

resultsSignificant differences were observed among the three types of lesions in terms of early arterial enhancement patterns, time to start of washout, and the degree of enhancement during the transitional phase (P < .01). The optimal diagnostic efficacy was achieved with the following criteria: washout start at 3.5 min for diagnosing HH (AUC = 0.974); mild hypoenhancement observed in 3 and 4 min for diagnosing HCC (AUC = 0.880 and 0.879); and marked hypoenhancement observed between 4 and 6 min for diagnosing LM (AUC = 0.911-0.916).

conclusionThe dynamic characteristics of the transitional phase in S-CEUS can effectively differentiate common FLLs, providing a valuable basis for precise clinical diagnosis.

Indexed as

Carcinoma, HepatocellularContrast MediaFerric CompoundsHemangiomaImage EnhancementIronLiver NeoplasmsOxidesAdultAgedDiagnosis, DifferentialFemaleHumansLiverMaleMiddle AgedContrast MediaFerric CompoundsIronOxidesSonazoidcontrast‐enhanced ultrasounddifferential diagnosisfocal liver lesionsSonazoidtransitional phase

Identifiers

PMID41439463
PMCPMC13148878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.