SynthesisJournal of oral rehabilitation2026
Exploring the Bidirectional Association Between Migraine and Temporomandibular Disorders: A Systematic Review and Meta-Analysis.
Synthesis in Journal of oral rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- One Molecule, Different Circuits? What Botulinum Toxin Can and Cannot Reveal About Craniocervical Comorbidity.Toxins · 2026Review
- Comorbidity of Temporomandibular Disorders, Anxiety, Depression, and Poor Sleep Quality in Episodic and Chronic Migraine: A Cross-Sectional Observational Study.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine and temporomandibular disorders (TMD) are comorbid conditions that are highly frequent among patients.
objectiveThis systematic review with meta-analysis (MA) aimed to evaluate the bidirectional association between migraine and TMD in adults.
methodsThe protocol was registered with the International Prospective Register of Systematic Reviews. The literature was searched in 5 main databases and 3 grey literature databases from inception until May 12, 2025. The review included observational cross-sectional studies that based TMD classification on the Research Diagnostic Criteria for TMD (RDC/TMD) or the Diagnostic Criteria for TMD (DC/TMD), and migraine was diagnosed according to any edition of the International Classification of Headache Disorders (ICHD). The risk of bias (Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument tools) and the certainty of evidence (GRADE) were assessed.
resultsFrom 7329 studies, 17 were included in the qualitative assessment and 6 in the quantitative analysis. Seven studies were classified as low risk of bias, nine as moderate, and one as high. The qualitative assessment demonstrated an association between both conditions. MA revealed that patients with migraine were significantly more likely to have TMD (OR = 6.08; 95% CI: 4.80-7.68), and patients with TMD were more likely to have migraine (OR = 2.64; 95% CI: 2.19-3.18). The certainty of evidence was rated high.
conclusionThe study identified a strong bidirectional association between migraine and TMD. Clinicians should systematically screen for both conditions, especially in the presence of one of them, to optimize treatment outcomes.
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