Evidence map›Paper›PMID 41439302›Full record

ArticleStroke2026

Preservation of Septo-Hippocampal Theta Oscillations via Cholinergic Protection Underlies Cognitive Recovery After Physical Exercise Post-Cardiac Arrest.

Fernando J Ferrier, Efrain J Perez-Lao, Rachel H Lipsky, Jake R Goldstein, Iris Escobar, Isabel Saul, Ami P Raval, Kunjan R Dave, Miguel A Perez-Pinzon

Abstract read
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In one paragraph

Article in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fernando J FerrierPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0001-6822-9002
Efrain J Perez-LaoPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0002-8586-5980
Rachel H LipskyPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.
Jake R GoldsteinPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0009-0008-3226-7910
Iris EscobarPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0001-9596-1717
Isabel SaulPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0002-8923-2240
Ami P RavalPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0003-1757-9947
Kunjan R DavePeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0002-0173-5338
Miguel A Perez-PinzonPeritz Scheinberg Cerebral Vascular Disease Research Laboratories, Department of Neurology (F.J.F., E.J.P.-L., R.H.L., J.R.G., I.E., I.S., A.P.R., K.R.D., M.A.P.-P.), University of Miami Leonard M. Miller School of Medicine, FL.ORCID 0000-0001-6555-8935

Funding

ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONR01NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MIGUEL A PEREZ-PINZON · 2003 to 2026
$6.7M
MECHANISMS OF NEUROPROTECTION AGAINST CARDIAC ARRESTR01NS045676 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2004 to 2024
$5.1M
ISCHEMIC PRECONDITIONING: MECHANISMS OF NEUROPROTECTIONRF1NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2022 to 2022
$1.7M
Mitochondria and Cerebral ischemia: intracellular signalingR01NS054147 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 2006 to 2009
$1.3M
ISCHEMIC PRECONDITIONING--MECHANISMS OF NEUROPROTECTIONR29NS034773 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PEREZ-PINZON, MIGUEL A · 1997 to 2001
$267k
NINDS NIH HHS R01 NS034773NINDS NIH HHS R01 NS045676NINDS NIH HHS R01 NS054147NINDS NIH HHS R29 NS034773NINDS NIH HHS RF1 NS034773
6 · The paper itself

Abstract

backgroundSignificant cognitive impairment follows cardiac arrest, yet few interventions restore memory. We previously demonstrated that physical exercise (PE) after asphyxial cardiac arrest (ACA) mitigates memory deficits and cell loss in the septal nuclei, but not in the hippocampus in rats. Given the critical role of the septum in modulating hippocampal theta oscillations, essential for memory, we hypothesize that PE preserves memory by safeguarding septal pacemaker neurons and septo-hippocampal theta activity.

methodsAdult male and female rats underwent 8 minutes of ACA or sham surgery and were randomly assigned to 5 days of treadmill running PE or sedentary conditions. Long- and short-term memory were assessed using fear conditioning and Y-maze tests. Immunohistochemistry quantified septal cholinergic and gamma-aminobutyric acid-ergic neurons. Local field potential recordings evaluated oscillatory activity across the septo-hippocampal network.

resultsACA induced persistent deficits in memory and disrupted theta oscillations throughout the septum and cornu ammonis 1 (CA1) laminae. These changes were accompanied by selective loss of cholinergic and gamma-aminobutyric acid-ergic septal neurons. PE markedly improved cognitive performance and restored theta power across the septo-hippocampal axis. Only cholinergic, not gamma-aminobutyric acid-ergic, neurons were preserved after PE. All effects were consistent across sexes. Importantly, enhancements in CA1 theta power closely tracked behavioral recovery, implying that reestablishment of cholinergic-driven network dynamics plays a central role in memory restoration.

conclusionsThis study is the first to directly implicate PE-induced cholinergic neuron preservation in the reengagement of septo-hippocampal circuitry and cognitive recovery post cardiac arrest. Rather than relying on hippocampal cell survival, the observed memory improvements appear to stem from reinstated interregional theta synchrony. These findings define a novel mechanistic pathway for promoting functional recovery via targeted circuit-level rehabilitation after ischemic brain injury.

Indexed as

Cholinergic NeuronsCognitionHeart ArrestHippocampusPhysical Conditioning, AnimalSeptal NucleiTheta RhythmAnimalsFemaleMaleRatsRats, Sprague-Dawleyelectrophysiologyheart arresthippocampusischemianeuronal plasticityneuroprotection

Identifiers

PMID41439302
PMCPMC13410823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.