ArticlePhysics and imaging in radiation oncology2025
Positioning uncertainties in single-target longitudinal segmentation for hippocampal-avoidance whole brain radiotherapy using volumetric modulated arc therapy.
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) aims to preserve cognitive function during treatment for brain metastases. This study investigated the potential of Single-Target Longitudinal Segmentation Volumetric Modulated Arc Therapy (VMAT) in HA-WBRT, which segments the planning target volume (PTV) into sub-PTVs, using single or dual arcs to generate s-VMAT and d-VMAT strategies. For 20 patients, s-VMAT and d-VMAT achieved lower median Dmean values of 8.3 Gy and 8.1 Gy, and reduced the median Dmax to 13.5 Gy and 12.8 Gy, compared to traditional coplanar/non-coplanar VMAT plans. These strategies showed enhanced robustness but required more monitor units and greater delivery complexity.
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