Evidence map›Paper›PMID 41439202›Full record

ArticleNature and science of sleep2025

The Role of Ferroptosis in Adenoid Hypertrophy in Children with Obstructive Sleep Apnea Syndrome.

Zilu Shen, Jingning Huang, Yunqiu Chu, Xiaoman Zhang, Huajun Xu, Hongming Xu, Jian Guan, Meizhen Gu

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PubMed Full text at PMC Publisher
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Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zilu Shen *Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China.
Jingning Huang *Department of Otolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, People's Republic of China.ORCID 0009-0006-6446-7795
Yunqiu ChuDepartment of Otolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, People's Republic of China.ORCID 0009-0008-5310-6016
Xiaoman ZhangDepartment of Otolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, People's Republic of China.
Huajun XuDepartment of Otolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, People's Republic of China.
Hongming XuDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China.
Jian GuanDepartment of Otolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, People's Republic of China.
Meizhen GuDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Obstructive sleep apnea (OSA) is a common sleep disorder in children, with adenoid hypertrophy was recognized as the main cause. While ferroptosis has been linked to adult OSA, its role in children with adenoid hypertrophy remains unclear. Here, we aimed to explore the potential role of ferroptosis in pediatric OSA-associated adenoid hypertrophy. Methods: We conducted RNA sequencing on adenoid tissues from children with OSA stratified by severity (mild-to-moderate, n=9; severe, n=9). Hub genes were identified by integrating differentially expressed genes (DEGs) with ferroptosis-related genes and constructing a protein-protein interaction (PPI) network. We further validated these findings in an independent cohort and primary cells. Results: KEGG enrichment analysis revealed significant alterations in ferroptosis-related pathways, including p53 signaling pathway and Glutathione metabolism (p < 0.05). We identified 108 ferroptosis-related DEGs (fold change: 0.45-6.42, adjusted p < 0.05) and subsequently pinpointed 8 hub genes through PPI network construction and Cytoscape analysis (fold change:0.61-1.81, adjusted p < 0.05). In clinical sample validation, mild-to-moderate tissues exhibited significant activation of ferroptosis. With the exception of Conclusion: This study helps us better understand how ferroptosis contributes to adenoid hypertrophy in children with OSA and also suggests that ferroptosis activation may attenuate disease advancement. Furthermore, the 7 hub genes are proposed as potential biomarkers and drug-binding targets.

Indexed as

adenoid hypertrophybioinformatic analysisferroptosisobstructive sleep apnea

Identifiers

PMID41439202
PMCPMC12720909

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.