Evidence map›Paper›PMID 41439155›Full record

ArticleEuropean urology open science2026

Alterations in the Cerebral Perivascular Space Network as a Potential Central Mechanism in Overactive Bladder: A Neuroimaging-Clinical Association Study.

Ye Hua, Yuwei Zhang, Feng Lu, Yuhua Zhou, Huihui Song, Deshui Yu, Kaixin Zhang, Qian Liu, Kaiyuan Gu, Tianyi Zhu and 4 more

Abstract read
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Article in European urology open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ye HuaDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Yuwei ZhangDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Feng LuDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Yuhua ZhouDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Huihui SongDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Deshui YuDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Kaixin ZhangDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Qian LiuDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Kaiyuan GuDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Tianyi ZhuDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.
Siyi FuWuxi School of Medicine, Jiangnan University, Wuxi, China.
Yong-Jie LuCentre for Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University, London, UK.
Yi FanDepartment of Pharmacology, Nanjing Medical University, Nanjing, China.
Ninghan FengDepartment of Urology, Department of Neurology, Department of Imaging, Physical Examination Center, Jiangnan University Medical Center, Wuxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: The role of the central nervous system (CNS) in overactive bladder (OAB) is not completely understood. Our aim was to investigate the association between alterations in the brain perivascular network and OAB, and to identify potential biomarkers for future intervention trials. Methods: This prospective study included 131 patients with OAB and 119 healthy individuals matched for age, sex, and education. High-resolution 3.0-T magnetic resonance imaging was used to measure brain glymphatic system (BGS) markers, including white matter (WM) and subcortical perivascular space (PVS) characteristics, the free water (FW) fraction, the Analysis Along the Perivascular Space index, and the choroid plexus volume. Spearman and partial correlation analyses were used to examine relationships between imaging results and clinical data. Linear regression and partial correlation analyses for 6-mo follow-up data were conducted to assess longitudinal associations between changes in BGS parameters and OAB symptom progression. Key findings and limitations: Patients with OAB exhibited notable BGS alterations, among which the WM-PVS count and FW fraction were strongly associated with clinical questionnaire scores. At 6-mo follow-up, progression of OAB symptoms was linked to a significant increase in brain FW content. However, we did not systematically evaluate how bladder function is related to changes in specific brain regions. Conclusions and clinical implications: This study reveals for the first time an association between BGS dysfunction and OAB symptom severity. Our findings reinforce the role of the CNS in contributing to OAB and highlight potential therapeutic targets. Patient summary: We used MRI (magnetic resonance imaging) brain scans and questionnaires on overactive bladder (OAB) symptoms to look at possible links between brain changes and OAB. Our results suggest that changes within the brain network may be a central mechanism in OAB. This new discovery may help in the development of new treatments for patients with OAB.

Indexed as

Central nervous systemGlymphatic systemNeuroimagingOveractive bladderPerivascular space network

Identifiers

PMID41439155
PMCPMC12721283

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.