Evidence map›Paper›PMID 41439147›Full record

ArticlePain reports2026

Pregabalin acts on Na

Rumi Kaneko, Takehito Ouchi, Maki Kimura, Hidetaka Kuroda, Tatsuya Ichinohe, Yoshiyuki Shibukawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rumi KanekoDepartment of Physiology, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan.
Takehito OuchiDepartment of Physiology, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4258-2152
Maki KimuraDepartment of Physiology, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan.
Hidetaka KurodaDepartment of Dental Anesthesiology, Kanagawa Dental University, Yokosuka, Kanagawa, Japan.
Tatsuya IchinoheDepartment of Dental Anesthesiology, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan.
Yoshiyuki ShibukawaDepartment of Physiology, Tokyo Dental College, Chiyoda-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Pregabalin, a first-line treatment for neuropathic pain, binds to the voltage-gated calcium channel auxiliary subunit alpha2delta-1, reducing neurotransmitter release. Transdermal pregabalin has also shown analgesic effects in neuropathic mouse models. However, its effects on epidermal cells remain unclear. Objectives: We aimed to investigate the action of pregabalin on the human Merkel cell line (MC). Methods: We used the cultured human Merkel cell line MCC 14/2 to measure intracellular free calcium concentration ([Ca Results: To examine effect of pregabalin on a chronic pain condition, we applied Lys-(Des-Arg Conclusion: These results suggested that the site of action of pregabalin to MCs is Ca

Indexed as

Na+–Ca2+ exchangerNeuropathic painPharmacological agentPregabalin

Identifiers

PMID41439147
PMCPMC12721786

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.