Evidence map›Paper›PMID 41439141›Full record

ArticleCurrent research in pharmacology and drug discovery2025

Salvianolic acid B decreases oxidative stress and alleviates the tumor-promoting effects of arecoline in oral cancer.

Hsuan-Yin Tung, Yi-Ling Ye, Chi-Maw Lin, Li-Shian Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in pharmacology and drug discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hsuan-Yin TungGraduate Institute of Life Sciences, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City, 114201, Taiwan.
Yi-Ling YeDepartment of Biotechnology, National Formosa University, No. 64, Wunhua Rd, Huwei Township, Yunlin County, 63201, Taiwan.
Chi-Maw LinDepartment of Otolaryngology, National Taiwan University Hospital, Yun-Lin Branch, No.579, Sec.2, YunLin Rd., Yunlin County, Douliou City, 640, Taiwan.
Li-Shian ShiDepartment of Biotechnology, National Formosa University, No. 64, Wunhua Rd, Huwei Township, Yunlin County, 63201, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arecoline, which is a primary alkaloid in areca nuts, contributes in key ways to the development of oral submucous fibrosis and the subsequent oral cancer through the induction of oxidative stress, promotion of fibrosis, and activation of oncogenic signaling. Salvianolic acid B (SAB) is the most abundant water-soluble phenolic compound found in

Indexed as

ArecolineFibrosisOral cancerOxidative stressRNA sequencingSalvianolic acid B

Identifiers

PMID41439141
PMCPMC12719042

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.