ArticleCurrent research in food science2025
Porous starch as an effective carrier for sustained release and bioactivity protection of cannabidiol full spectrum oil.
Article in Current research in food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Full-spectrum cannabidiol oil (CFSO) has attracted growing attention across industries for its multiple health benefits, but its poor water solubility and low bioavailability remain unresolved challenges. In this study, porous starch (PS) was used as a wall material to encapsulate CFSO, and the physicochemical properties, water solubility, bioavailability, and antioxidant activity of the encapsulated product were evaluated. Results confirmed the successful preparation of PS-CFSO. Using Box-Behnken design response surface methodology, the maximum encapsulation efficiency (80.69 ± 0.71 %) was achieved under optimal parameters: CFSO concentration of 75 mg/mL, PS-to-CFSO mass ratio of 7.6:1 (g/g), and loading time of 41 min. CFSO was encapsulated in PS in an amorphous state, and PS increased CFSO's thermal decomposition temperature. Compared with free CFSO, PS-CFSO showed a 17.92-fold increase in water solubility, a 4.74-fold higher release rate in simulated gastric fluid, and a 4.13-fold higher release rate in simulated intestinal fluid. PS-CFSO release followed pseudo-Fickian diffusion and first-order kinetics. Additionally, its antioxidant activity was enhanced by over 20 %. Overall, This study expands the application of starch-based carriers and provides critical guidance for developing CFSO delivery systems with high encapsulation efficiency, stability, and bioavailability, thereby broadening CFSO's prospects in the food and pharmaceutical industries.
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