ArticleFrontiers in oncology2025
Rapid postoperative platelet decline in a lung adenocarcinoma with sarcomatoid differentiation and concomitant JAK2 V617F mutation: a case report.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Curcumin in colorectal cancer: preventive strategies and therapeutic mechanisms.Cancer chemotherapy and pharmacology · 2025Review
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2 authors.
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Abstract
Background: Lung cancer is one of the leading causes of cancer incidence and mortality worldwide. At the molecular level, its development involves aberrations in multiple oncogenic pathways. Here, we report a rare case of lung adenocarcinoma with sarcomatoid differentiation and profound thrombocytosis (1,350 × 10 Case presentation: A 75-year-old female underwent VATS wedge resection for pathological stage IB lung adenocarcinoma. Platelet counts dropped from 1,350 to 572 × 10 Conclusion: This case represents a rare coexistence of JAK2 V617F, MET, and TP53 mutations in lung adenocarcinoma. A marked postoperative decline in platelet count was observed without adjuvant therapy, suggesting a possible tumor-associated reactive thrombocytosis rather than a primary hematologic disorder. Recognition of such platelet dynamics may aid in the clinical assessment and follow-up of lung cancer patients.
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