Evidence map›Paper›PMID 41438893›Full record

ArticleRespiratory medicine case reports2025

A case of clopidogrel-induced organizing pneumonia evaluated by lung biopsy and confirmed by accidental re-administration.

Shogo Toyama, Kiminobu Tanizawa, Masatsugu Ouchi, Saiki Yoshimura, Naoki Fujimoto, Takanori Ito, Takuma Imakita, Issei Oi, Osamu Kanai, Kohei Fujita and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shogo ToyamaDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Kiminobu TanizawaDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Masatsugu OuchiDivision of Thoracic Surgery, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Saiki YoshimuraDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Naoki FujimotoDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Takanori ItoDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Takuma ImakitaDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Issei OiDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Osamu KanaiDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Kohei FujitaDivision of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Satoru SawaiDivision of Thoracic Surgery, Center for Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Hiroki MoriyoshiDepartment of Diagnostic Pathology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Akihiko YoshizawaDepartment of Diagnostic Pathology, Nara Medical University, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clopidogrel-induced interstitial lung disease (ILD) is a rare but significant adverse effect. Herein, we report a case of organizing pneumonia following clopidogrel administration, confirmed by histopathology and accidental re-administration, fulfilling Camus's criteria for drug-induced ILD. The patient responded well to corticosteroid therapy. A systematic literature review identified nine additional cases, with clinical presentations ranging from ground-glass opacities to eosinophilic infiltration. Most cases involved immune-mediated mechanisms. This report highlights the diagnostic challenges of clopidogrel-induced ILD and underscores the importance of considering drug etiology in organizing pneumonia.

Indexed as

ClopidogrelDrug-Induced Lung Injury (DILD)Interstitial Lung Disease (ILD)Organizing pneumonia

Identifiers

PMID41438893
PMCPMC12720126

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.