Evidence map›Paper›PMID 41438879›Full record

ArticleJPRAS open2026

Efficacy of high-intensity focused ultrasound for treating upper and lower eyelid sagging.

Yousun Hwang, Jin-Hyun Kim, Han Earl Lee, Isaac Wong Kai Jie, Jong Keun Song, Arash Jalali, Isabella Rosellini, Jesper Thulesen, Massimo Vitale, Eun-Jae Kim and 1 more

Abstract read
In one paragraph

Article in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yousun HwangHaedrin Clinic, Center for Aesthetic Medicine, Seoul, Korea.
Jin-Hyun KimYou and I Clinic, Seoul, Korea.
Han Earl LeeOpening Plastic Surgery Clinic, Korea.
Isaac Wong Kai JieThe Artisan Clinic Private Limited, 435 Orchard Road, #20-03, Singapore 238877.
Jong Keun SongPixelab plastic surgery clinic, Seoul, Korea.
Arash JalaliOne Clinic MD, Vancouver, Canada.
Isabella RoselliniAvery Beauty Clinic and Avena Aesthetics Indonesia.
Jesper ThulesenCapitol Eye Clinic/Clinic Aesthetica, Copehagen, Denmark.
Massimo VitalePrivate practice in Bologna, Italy.
Eun-Jae KimClassys Inc., Seoul, Korea.
Kyu-Ho YiDivision in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 PLUS Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seoul, 03722, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Eyelid sagging is a frequent concern among aging patients, yet achieving noticeable improvement with noninvasive methods remains challenging. Objective: This prospective cohort study evaluated the efficacy and safety of high-intensity focused ultrasound (HIFU) for improving upper and lower eyelid sagging. Methods: Thirty-four Korean women (aged 31-67 years) with mild to moderate eyelid laxity underwent a single session of HIFU (ULTRAFORMER MPT) using a 2.0-mm, 4-MHz probe, delivering 120 shots to the periocular region. Outcomes were assessed at 12 weeks via a four-point scale rated by blinded clinicians and patients. Eyelid length was measured using standardized photography. Results: Mean eyelid length decreased by 0.94 ± 0.34 mm ( Conclusion: HIFU is a safe and effective noninvasive option for improving both upper and lower eyelid sagging, with high patient satisfaction and minimal adverse effects.

Indexed as

Eyelid saggingHigh-intensity focused ultrasoundNoninvasive rejuvenationPeriocular treatmentSkin tightening

Identifiers

PMID41438879
PMCPMC12719753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.