ArticleGMS hygiene and infection control2025
Early detection of central line-associated bloodstream infection in intensive care unit patients using the systemic inflammatory response index (SIRI).
Article in GMS hygiene and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Systemic Inflammatory Response Index (SIRI) Among Patients With Sepsis: A Retrospective Observational Study.Cureus · 2026Article
- Comparative evaluation of the aggregate index of systemic inflammation (AISI) and its modified version for early detection of central line-associated bloodstream infection: a pilot study using machine learning techniques.GMS hygiene and infection control · 2026Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: Central line-associated bloodstream infections (CLABSIs) are life-threatening complications in critically ill patients, necessitating early identification for timely intervention. This study evaluates the predictive performance of Systemic Inflammatory Response Index (SIRI), a novel composite marker derived from routine blood counts, for early prediction of CLABSI within first two calendar days following central venous catheter (CVC) insertion. Method: In this observational study at a tertiary ICU, 234 adults with CVCs for over two days were classified as CLABSI-positive or negative per CDC/NHSN criteria. SIRI was calculated using the formula (neutrophils×monocytes/lymphocytes) based on day 2 complete blood counts. Logistic regression and receiver operating characteristic (ROC) curve analysis was done to determine diagnostic performance. Results: CLABSI was diagnosed in 39 patients. Median SIRI values were significantly higher in CLABSI group (37.3 vs. 12.0; p<0.001). In univariate logistic regression, SIRI emerged as an independent predictor of CLABSI (OR=1.0097; 95% CI: 1.001-1.018; p=0.015). ROC analysis demonstrated a moderate discriminative power with AUROC=0.72 (95% CI: 0.64-0.80). At optimal threshold, SIRI achieved 84.6% sensitivity, 52.8% specificity, 58.1% accuracy, 26.4% positive predictive value (PPV) and a notably high negative predictive value (NPV) of 94.5%, supporting its value as an early rule-out marker for CLABSI. Conclusion: SIRI, derived from routine complete blood counts, shows strong potential as a non-invasive, early screening marker for CLABSI. Its high sensitivity and NPV support its use for early rule-out, especially in settings lacking rapid diagnostics. Further prospective validation is warranted.
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