ArticleContemporary oncology (Poznan, Poland)2025
Immunometabolic landscape of glioblastoma - a comparative analysis of circulating cytokines and biochemical markers.
Article in Contemporary oncology (Poznan, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Glioblastoma (GBM) is the most aggressive primary brain tumour in adults. Systemic immunometabolic alterations are increasingly implicated in its pathogenesis, yet sex- and age-specific patterns remain unclear, especially in Uzbekistan. To characterize circulating cytokine and biochemical profiles in newly diagnosed GBM patients and assess sex- and age-related differences. Material and methods: This cross-sectional study included 26 GBM patients (18 females, 8 males) and 26 matched healthy controls. Serum interleukin (IL)-10, IL-1β, IL-6, tumor necrosis factor-α, and IFN-γ were measured by enzyme-linked immunosorbent assay, and biochemical parameters (alkaline phosphatase, alanine aminotransferase - ALT, aspartate aminotransferase - AST, bilirubin, calcium, magnesium, iron, creatinine, uric acid, lactate dehydrogenase - LDH, phosphorus) were analysed by automated assays. Data were evaluated using ANOVA, t-tests, correlations, and principal component analysis ( Results: No sex-based differences were observed ( Conclusions: Glioblastoma-related immunometabolic profiles are influenced mainly by tumour-intrinsic factors rather than sex, while age contributes to metabolic shifts. These findings provide novel regional data and support cytokine-biochemical profiling for biomarker development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.