Evidence map›Paper›PMID 41438810›Full record

ArticleContemporary oncology (Poznan, Poland)2025

Cytotoxicity and apoptotic effects of the ethyl acetate fraction of

Eka Roina Megawati, Hakim Bangun, Imam Budi Putra, Muhammad Rusda

Abstract read
In one paragraph

Article in Contemporary oncology (Poznan, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eka Roina MegawatiDepartment of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Hakim BangunDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Imam Budi PutraDepartment of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Muhammad RusdaPhilosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to investigate the cytotoxicity and apoptotic effects of the ethyl acetate fraction of Material and methods: The ethyl acetate fraction was obtained through maceration followed by fractionation with n-hexane and ethyl acetate. Cytotoxicity was assessed using the MTT assay to determine the IC Results: The ethyl acetate fraction of ZA fruit exhibited cytotoxic activity on B16F10 melanoma cells, with an IC Conclusions: The ethyl acetate fraction of ZA fruit demonstrated cytotoxic effects and induced apoptosis in B16F10 melanoma cells, potentially through caspase-3 activation.

Indexed as

apoptosisB16F10ethyl acetate fractionmelanomaZanthoxylum acanthopodium DC

Identifiers

PMID41438810
PMCPMC12721240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.