ArticleContemporary oncology (Poznan, Poland)2025
Real-world outcomes of immune checkpoint inhibitor monotherapy in later lines of recurrent/metastatic cervical cancer - evidence from a rescue access program in Poland.
Article in Contemporary oncology (Poznan, Poland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Immune-Related Adverse Events of Cemiplimab Therapy in Advanced Cervical Cancer-Data from the Polish-Czech Cervical Cancer Immunotherapy Group (PCCIG-01) with a Review of the Literature.Antibodies (Basel, Switzerland) · 2026Article
- Design of Experiments in the Formulation and Characterization of 3D-Printed Vaginal Films Loaded with Curcumin Solid Lipid Nanoparticles for Cervical Dysplasia.Pharmaceuticals (Basel, Switzerland) · 2026Article
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11 authors.
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Abstract
Introduction: Immune checkpoint inhibitors (ICIs) are a therapeutic option for recurrent/metastatic cervical cancer (r/mCC) following platinum-based chemotherapy. However, real-world data on their effectiveness and safety remain limited, particularly in Eastern Europe. This study evaluates the real-world outcomes of ICI monotherapy in pretreated patients with r/mCC. Material and methods: This multicentre retrospective study included 39 patients with r/mCC who received ICI monotherapy (cemiplimab or pembrolizumab) after disease progression on platinum-based chemotherapy in 5 reference centres in Poland. The primary endpoints were overall survival (OS), progression-free survival (PFS), objective response rate, and disease control rate (DCR). The secondary endpoint was treatment safety. Kaplan-Meier estimates were used for survival analysis, and Cox proportional hazards models assessed prognostic factors, with p < 0.05 considered statistically significant. Results: After a median follow-up of 8.8 months, the median PFS was 5.7 months (95% confidence interval [CI] 4.9-6.4), and the median OS was 10.9 months (95% CI: 7.3-14.5). The objective response rate was 23% ( Conclusions: Immune checkpoint inhibitor monotherapy demonstrated modest efficacy in pretreated patients with r/mCC, with a manageable safety profile and irAEs of predictive significance for PFS.
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