ArticleJournal of Indian Society of Periodontology
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- LL-37-based oral antimicrobial therapeutics: translational challenges and future directions-a narrative review.Odontology · 2026Review
- A novel approach, exploring subgingival temperature changes over time since death: An animal study.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periodontitis is a chronic immune-inflammatory disease influenced by multiple factors. LL-37, an antimicrobial peptide, contributes to host defense, immune regulation, and tissue repair. Its subgingival expression following nonsurgical periodontal therapy remains underexplored. This study evaluates LL-37 gene expression as a potential biomarker for response to scaling and root planing (SRP). Materials and Methods: Thirty systemically healthy patients (17 males and 13 females; aged 30-50 years) with Stage II or III periodontitis were included. Clinical parameters - probing pocket depth (PPD), clinical attachment level (CAL), and modified sulcular bleeding index (mSBI) - were recorded at baseline and 1 month post-SRP. Subgingival epithelial tissue samples were collected at both time points for quantitative real-time polymerase chain reaction analysis of LL-37 gene expression. Data were statistically analyzed. Results: All clinical parameters improved significantly posttherapy. In Stage II, PPD reduced from 4.26 ± 0.53 to 3.25 ± 0.49 mm; CAL from 4.63 ± 0.32 to 3.60 ± 0.62 mm; and mSBI from 2.88 ± 0.55 to 1.45 ± 0.57. In Stage III, PPD decreased from 6.29 ± 1.24 to 4.40 ± 0.87 mm; CAL from 7.85 ± 1.11 to 5.81 ± 0.73 mm; and mSBI from 3.63 ± 0.37 to 3.22 ± 0.41 (all Conclusion: SRP significantly improved clinical outcomes and upregulated LL-37 expression, supporting its potential as a biomarker for early periodontal healing.
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Registered trials
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