ArticleJournal of Indian Society of Periodontology
Comparative evaluation of leucine-rich alpha-2 glycoprotein in the gingival crevicular fluid of periodontally healthy and Stage 1 Grade A periodontitis individuals and its response to nonsurgical periodontal treatment: A clinicobiochemical interventional study.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: With advances in diagnostic aids, the risk of periodontal disease can be identified and quantified by objective measures such as biomarkers. This research aims to assess the role of human leucine-rich alpha-2 glycoprotein (LRG) levels among healthy individuals and those suffering from periodontitis. Materials and Methods: An interventional clinicobiochemical study was performed on 50 individuals, who were systemically healthy and between 30 and 60 years. They were randomly allocated into two groups. Group I involved periodontally healthy and Group II involved Stage 1 Grade A periodontitis patients. Group II individuals were recalled after 6 weeks (Group X). Clinical outcomes such as probing pocket depth (PPD), clinical attachment levels (CAL), gingival index (GI) as well as plaque index (PI) were assessed. LRG levels from the gingival crevicular fluid were assessed and compared. Statistical analysis was performed with a paired Results: Statistically significant differences in clinical outcomes were observed between Group I, Group II, and Group X by evaluating PI, GI, and LRG levels. Similarly, a notable difference was observed between Group II and Group X in clinical outcomes such as PPD and CAL. Conclusion: LRG can be used as a biomarker and shows a significant potential to be utilized as a future diagnostic tool for the detection of the severity of periodontal disease.
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