Evidence map›Paper›PMID 41438767›Full record

ArticleFrontiers in immunology2025

Multi-omics spatial characteristics of CD8

Shipeng Li, Ju Ma, Xinqiang Li, Bingbing Qiao, Liancai Wang, Deyu Li, Hua Zhou, Haixu Xu, Jinzhen Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shipeng Li *Department of Hepatopancreaticobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China.
Ju Ma *Department of Hepatopancreaticobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China.
Xinqiang Li *Organ Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China.
Bingbing QiaoDepartment of Hepatopancreaticobiliary Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Liancai WangDepartment of Hepatopancreaticobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China.
Deyu LiDepartment of Hepatopancreaticobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, China.
Hua ZhouEndocrinology and Metabolism Center, Henan Key Laboratory of Rare Diseases, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Haixu XuDepartment of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Jinzhen CaiOrgan Transplantation Center, Affiliated Hospital of Qingdao University, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Understanding CD8 Methods: This study employs a multi-omics approach to analyze the spatial distribution and intercellular interactions of TRM cells in HCC tissues using radiomics, single-cell sequencing, and multiplex immunofluorescence histochemistry (m-IHC). Results: Our results show that the number of CD8 Discussion: Immunotherapy can modify the spatial characteristics of CD8

Indexed as

Carcinoma, HepatocellularCD8-Positive T-LymphocytesImmunotherapyLiver NeoplasmsLymphocytes, Tumor-InfiltratingMemory T CellsFemaleHumansImmune Checkpoint InhibitorsImmunologic MemoryMaleMultiomicsSingle-Cell AnalysisTumor MicroenvironmentImmune Checkpoint InhibitorsCD8+TRM cellshepatocellular carcinomaimmune checkpoint blockadeimmunotherapytissue-resident memorytumor-infiltrating immune cells

Identifiers

PMID41438767
PMCPMC12719432

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.