ReviewFrontiers in immunology2025
Cancer stem cells in hepatocellular carcinoma: therapy resistance and emerging treatments.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Article
- Review
- γ-terpinene inhibits the progression of hepatocellular carcinoma by regulating the PTEN/PI3K/Akt signaling pathway mediated glycolysis.Scientific reports · 2026Article
- Down-regulation of THBS2 inhibits the malignant progression of Burkitt lymphoma by blocking the PI3K/AKT/c-MYC pathway.Frontiers in oncology · 2026Article
- ZIF-8 Nanocarrier-Based Co-Delivery of Curcumin and 5-Fluorouracil for Synergistic Antitumor Activity in Hepatocellular Carcinoma.International journal of general medicine · 2026Article
- Multidimensional tumor heterogeneity and its role in therapeutic resistance.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) imposes a significant global cancer mortality burden, with conventional therapies (surgery, ablation, chemotherapy, radiotherapy) and newer modalities (targeted agents, immune checkpoint inhibitors) limited by therapeutic resistance. Notably, liver cancer stem cells (Liver-CSCs)-defined by their self-renewal and unlimited proliferative capacity-drive tumor initiation, metastasis, heterogeneity, and therapy resistance. This review synthesizes current knowledge on Liver-CSCs, focusing on their distinctive features, supporting microenvironments, signaling pathways, and therapy resistance mechanisms. We also examine novel therapeutic strategies targeting these cells. Clinically, we evaluate recent research, identify knowledge gaps, and suggest potential directions for advancing HCC therapies. Finally, we discuss how these insights may inform development of more effective treatments to improve clinical HCC management. Understanding Liver-CSC biology and treatment resistance mechanisms will enable better-tailored therapies to overcome these challenges and enhance patient outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.