Evidence map›Paper›PMID 41438733›Full record

ArticleBlood vessels, thrombosis & hemostasis2026

Mutations in histone lysine methyltransferase genes are associated with autoimmune cytopenias: a single-center study.

Zhengrui Xiao, Daniel Cole, Varun Gupta, Jesus D Anampa, Noelle Townsend, Gretchen Mackie, Ami Sanghvi, Rahul Thakur, Parth Patel, Herbert Lachman and 1 more

Abstract read
In one paragraph

Article in Blood vessels, thrombosis & hemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhengrui XiaoDivision of Hematology, Department of Hematology-Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Daniel ColeDivision of Hematology-Oncology, Montefiore Nyack Hospital, Nyack, NY.
Varun GuptaDepartment of Oncology, Albert Einstein College of Medicine, Bronx, NY.
Jesus D AnampaDepartment of Hematology-Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Noelle TownsendDivision of Hematology, Department of Hematology-Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Gretchen MackieDivision of Hematology, Department of Hematology-Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Ami SanghviAlbert Einstein College of Medicine, Bronx, NY.
Rahul ThakurDepartment of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Parth PatelDepartment of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Herbert LachmanDepartment of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Irina MurakhovskayaDivision of Hematology, Department of Hematology-Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic dysregulation is increasingly recognized as a contributor to autoimmunity and autoimmune cytopenias (AIC). Histone lysine methyltransferases (MTs) are key regulators of gene expression through epigenetic modification. Germline MT mutations are associated with immunodeficiency syndromes such as Kabuki syndrome, which frequently co-occurs with AIC, while somatic

Identifiers

PMID41438733
PMCPMC12719652

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.