Evidence map›Paper›PMID 41438719›Full record

ArticleFrontiers in allergy2025

Effect of low salicylate diet and blood salicylate level on the symptom control of chronic spontaneous urticaria.

Sercan Guloglu, Ayse Bilge Ozturk, Said Incir, Betul Buyuktiryaki, Asli Gelincik, Semra Demir, Ebru Arik Yilmaz, Pinar Uysal, Mustafa Arga, Ozlem Cavkaytar and 8 more

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Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Sercan GulogluKoc University Research Center for Translational Medicine (KUTTAM), Istanbul, Türkiye.
Ayse Bilge OzturkDivision of Allergy and Immunology, Department of Pulmonary Medicine, School of Medicine, Koc University, Istanbul, Türkiye.
Said IncirDepartment of Clinical Biochemistry, School of Medicine, Koc University, Istanbul, Türkiye.
Betul BuyuktiryakiDivision of Pediatric Allergy, School of Medicine, Koc University, Istanbul, Türkiye.
Asli GelincikDivision of Immunology and Allergic Diseases, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Semra DemirDivision of Immunology and Allergic Diseases, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Ebru Arik YilmazDivision of Pediatric Allergy, Faculty of Medicine, Pamukkale University, Denizli, Türkiye.
Pinar UysalDivision of Pediatric Allergy and Immunology, School of Medicine, Adnan Menderes University, Aydin, Türkiye.
Mustafa ArgaDivision of Pediatric Allergy and Immunology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Türkiye.
Ozlem CavkaytarDivision of Pediatric Allergy and Immunology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Türkiye.
Reyhan GumusburunDivision of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Türkiye.
Tugba GokceDivision of Pediatric Endocrinology and Diabetes, Koc University Hospital, Istanbul, Türkiye.
Merve PoyrazDivision of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Kirikkale University, Kirikkale, Türkiye.
Ayse BacciogluDivision of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Kirikkale University, Kirikkale, Türkiye.
Emek KocaturkDepartment of Dermatology, School of Medicine, Koc University, Istanbul, Türkiye.
Tuba ReçberDepartment of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye.
Emirhan NemutluDepartment of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye.
Cansin SackesenKoc University Research Center for Translational Medicine (KUTTAM), Istanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Up to 30% of chronic spontaneous urticaria (CSU) patients and 24% of children with CSU may have an NSAIDs-exacerbated cutaneous disease (NECD). Some vegetables and fruits are rich in salicylate. Salicylates in food can exacerbate symptoms in CSU patients. Aim: Our aim is to investigate the effect of a low salicylate diet on urticaria severity, quality of life, blood salicylate level and urine arachidonic acid pathway metabolites. Methods: Patients followed a fourweek low salicylate diet. Chronic urticaria quality of life questionnaire (CU-Q2oL) and 4 Days-Urticaria Activity Scores (UAS4) were recorded and blood and urine samples were collected at baseline and after the low salicylate diet. Urine Leukotriene-E4, Prostaglandin-E2, Prostaglandin-F2 Results: A total of 36 CSU patients were included in the study. The CU-Q2oL scores significantly decreased from 33.7 to 20.7 ( Conclusion: Our findings suggest that a low salicylate diet may help to reduce the severity of urticaria and improve quality of life by lowering blood salicylate levels. However, the diet had no impact on urinary LTE4, PGDE2, PGDF2α, and TXA2 levels.

Indexed as

chronic spontaneous urticarialow salicylate dietsalicylatesalicylic acidurticaria

Identifiers

PMID41438719
PMCPMC12719075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.