Evidence map›Paper›PMID 41438660›Full record

ArticleRadiology case reports2026

FH-deficient uterine leiomyoma: A rare case report highlighting diagnostic and clinical challenges.

Wissal Jaafar, Yasmine Chiba, Malak Medemagh, Souha Gabbouj, Mehdi Bouassida, Nahed Khalifa, Imen Ganzoui, Mechaal Mourali

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Wissal JaafarDepartment of Gynecology and Obstetrics, Bougatfa Hospital, Bizerte, Tunisia.
Yasmine ChibaDepartment of Gynecology and Obstetrics, Bougatfa Hospital, Bizerte, Tunisia.
Malak MedemaghDepartment of Gynecology and Obstetrics, Bougatfa Hospital, Bizerte, Tunisia.
Souha GabboujDepartment of Radiology, Habib Bougatfa Hospital, Bizerte, Tunisia.
Mehdi BouassidaDepartment of Gynecology and Obstetrics, Bougatfa Hospital, Bizerte, Tunisia.
Nahed KhalifaDepartment of Gynecology and Obstetrics, Bougatfa Hospital, Bizerte, Tunisia.
Imen GanzouiDepartment of Radiology, Habib Bougatfa Hospital, Bizerte, Tunisia.
Mechaal MouraliDepartment of Gynecology and Obstetrics, Bougatfa Hospital, Bizerte, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fumarate hydratase (FH)-deficient uterine leiomyomas are a rare subtype of fibroids with distinctive histological and immunohistochemical features. We report the case of a 44-year-old nulligravida presenting with chronic pelvic pain for 2 years and an enlarged abdomen. Pelvic ultrasound revealed a polymyomatous uterus with the largest myoma measuring 14 cm, and MRI confirmed multiple leiomyomas with signs of pelvic congestion. The patient underwent polymyomectomy, and histopathological analysis identified an Fumarate hydratase (FH)-deficient leiomyoma. This entity is important to recognize given its potential association with Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), warranting careful diagnosis, appropriate surgical management, and consideration of genetic counseling.

Indexed as

FH-deficient leiomyomaFumarate hydratase deficiencyMyomectomyPelvic painUterine leiomyoma

Identifiers

PMID41438660
PMCPMC12720321

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