Evidence map›Paper›PMID 41438593›Full record

ArticleCardiovascular therapeutics2025

Impact of Hyperhomocysteinemia on Valve Calcification and Prognosis in Rheumatic Mitral Valve Surgery.

Songhao Jia, Peiyi Liu, Maozhou Wang, Hongkai Zhang, Tingting Liu, Xian Yang, Ruihan Jia, Xiaoyan Hao, Xiaohan Zhong, Meili Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Songhao JiaDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Peiyi LiuDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Maozhou WangDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Hongkai ZhangDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Tingting LiuEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0000-0002-1677-0371
Xian YangEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0009-0002-7595-0177
Ruihan JiaEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0009-0007-4819-9281
Xiaoyan HaoEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0000-0002-3896-5727
Xiaohan ZhongDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Meili WangBeijing Laboratory of Cardiovascular Precision Medicine, Beijing Municipal Education Commission, Beijing, China.
Wei LuoBeijing Laboratory of Cardiovascular Precision Medicine, Beijing Municipal Education Commission, Beijing, China.
Yihua HeEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0000-0002-4985-2365
Lei XuDepartment of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Xu MengDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.
Hongjia ZhangDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0000-0002-5737-4084
Wenjian JiangDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0000-0003-3868-6573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Hyperhomocysteinemia is a risk factor for cardiovascular disease, but its impact on valve disease is lacking in research. This study was aimed at investigating the impact of hyperhomocysteinemia on rheumatic mitral valve calcification and prognosis in patients undergoing surgery. Methods: This study included 672 patients with severe rheumatic mitral valve stenosis who underwent surgery between January 2016 and December 2022. Patients were stratified by preoperative homocysteine levels. Mitral valve pathology was assessed by echocardiography and coronary CTA, with all-cause mortality as the primary mid-term endpoint. Results: Among this surgical cohort of 672 patients with severe rheumatic mitral stenosis, 208 (31.0%) patients were identified with hyperhomocysteinemia. Imaging assessment revealed that these patients had a higher Agatston score for mitral valve calcification (37.47 vs. 17.19, Conclusions: In patients undergoing surgery for rheumatic heart disease, hyperhomocysteinemia was associated with the formation of rheumatic mitral valve calcification and increased mid-term postoperative mortality.

Indexed as

CalcinosisCardiac Surgical ProceduresHomocysteineHyperhomocysteinemiaMitral ValveMitral Valve StenosisRheumatic Heart DiseaseAdultAgedBiomarkersFemaleHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentBiomarkersHomocysteinehyperhomocysteinemiamitral valve calcificationprognosisrheumatic heart disease

Identifiers

PMID41438593
PMCPMC12721752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.