Evidence map›Paper›PMID 41438588›Full record

ReviewJournal of Cancer2026

Biomarkers for Recurrence and Prognosis in Metastatic Urothelial Cancer: Emerging Clinical Applications.

Alicia Sánchez Cendra, Linda Rocio Ospino, Leonel Pekarek, Yumna Dbouk, Sami Chnaiker, Ana Luengo, Tania Villamor, Amalia Corralo, Raul Diaz-Pedrero, Laura Lopez-Gonzalez and 8 more

Abstract readReview
In one paragraph

Review in Journal of Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alicia Sánchez CendraOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Linda Rocio OspinoOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Leonel PekarekOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Yumna DboukOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Sami ChnaikerOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Ana LuengoOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Tania VillamorOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Amalia CorraloOncology Service, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
Raul Diaz-PedreroRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
Laura Lopez-GonzalezRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain.
Miguel A SaezDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.
Majd N Michael AlhaddadinDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.
María Belén Alonso-BartolomeDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.
Carlos Casanova-MartínDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.
Melchor Alvarez-MonDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.
Leonor Garcia RodriguezGroup for Research in Community Care and Social Determinants of Health, University of Alcalá, Madrid, Spain.
Silvestra Barrena-BlázquezDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.
Miguel A OrtegaDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, Network Biomedical Research Center for Liver and Digestive Diseases (CIBEREHD), University of Alcalá, 28801 Alcala de Henares, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urothelial cancer (UC) remains a highly recurrent and heterogeneous malignancy in which reliable biomarkers for recurrence and prognosis are needed, particularly in the metastatic setting. In recent years, the identification and validation of biomarkers have become an essential pillar for improving the diagnosis, monitoring, and prognosis of this disease. This review summarizes and analyzes recent advances in the study of serological, urinary, histological, genetic, and microRNA biomarkers, as well as emerging tools such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Together, these non-invasive markers show significant potential to complement conventional diagnostic techniques, optimize risk stratification, and support a more personalized therapeutic approach. Furthermore, the integration of new sequencing technologies and liquid biopsy methods is opening new perspectives for the early detection of recurrence and the dynamic assessment of treatment response. However, the routine clinical implementation of these biomarkers still requires validation through standardized prospective studies.

Indexed as

biomarkerscirculating tumor cellscirculating tumor DNAFGFR3liquid biopsymetastaticmicroRNAprognosisrecurrenceurothelial cancer

Identifiers

PMID41438588
PMCPMC12719594

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.