ArticleFrontiers in pharmacology2025
Moxibustion combined with chemotherapy inhibits gastric cancer growth by modulating the immunosuppressive microenvironment involving the Treg/IL-10/TGF-β1 axis.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The immunosuppressive microenvironment poses a major challenge in gastric cancer (GC) therapy. Moxibustion, based on the "Guben Peiyuan" theory, shows potential in oncology, but its immunomodulatory mechanisms in GC remain elusive. Methods: This study integrated bioinformatics analysis with animal experiments. We analyzed pan-cancer expression and prognostic value of IL-10 and TGF-β1 via TCGA/GTEx databases. A mouse model of MFC gastric cancer was established to evaluate the effects of moxibustion (ST36, CV12, CV6, CV4), chemotherapy (5-FU), and their combination on tumor growth and the immune microenvironment. Results: Bioinformatics indicated that IL-10 and TGF-β1 were upregulated in GC, positively correlated with FOXP3 Conclusion: This study is the first to demonstrate that moxibustion synergizes with chemotherapy to inhibit gastric cancer growth through bidirectional remodeling of the immune microenvironment, simultaneously attenuating immunosuppression and boosting immune attack. Our findings provide a novel mechanistic insight into the integrated "Guben Peiyuan" and Western medicine strategy for GC.
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