ArticleCancer management and research2025
Vitamin K1 Induced Cytotoxic Effects and Transcriptomic Analysis in Jurkat T Lymphocyte Leukemia Cells.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Vitamin K1 (VK1) has been proved to have anticancer properties in various cancer cells. However, little is known about the effects of VK1 on hematologic malignancies. The aim of this study was to evaluate the cytotoxic effects of VK1 on Jurkat T Lymphocyte Leukemia Cells (Jurkat T cells), as well as to investigate the changes in gene expression. Methods: Jurkat T cells and normal human peripheral blood mononuclear cells (PBMCs) were treated with VK1 at different concentrations, and the cell viabilities were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell apoptosis was detected by Annexin V-FITC cell apoptosis detection kit and the cell cycle was determined by PI staining and flow cytometric analysis. Differentially expressed genes (DEGs) of Jurkat T cells induced by VK1 were analyzed by RNA sequencing. The mRNA expression of Results: VK1 showed an obviously antiproliferative effect on Jurkat T cells but no any effects on normal human PBMCs. VK1 induced Jurkat T cells apoptosis and cell cycle arrest at G0/G1 phase. A total of 21 down-regulated and 34 up-regulated genes were identified by transcriptome analysis. We selected Conclusion: VK1 has cytotoxic effects and transcriptional regulation of multiple genes on Jurkat T cells. The genes of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.