Evidence map›Paper›PMID 41438472›Full record

ArticleJournal of translational internal medicine2025

Endotoxin retention in adipose tissue leading to persistent hypotension in catecholamine-dependent acute obstructive suppurative cholangitis.

Kun Li, Sibo Zhu, Chun Ye, Yue Ding, Jiangxi Liu, Yufeng Wang, Zhiyong Wang, Wenfeng Li, DongHua Yang, Xiuyan Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kun LiGeneral Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Sibo ZhuMOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Chun YeGeneral Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yue DingGeneral Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiangxi LiuGeneral Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yufeng WangGeneral Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhiyong WangSurgery Department, Chongyi County People's Hospital, Ganzhou, Jiangxi Province, China.
Wenfeng LiSurgery Department, Chongyi County People's Hospital, Ganzhou, Jiangxi Province, China.
DongHua YangAdministrative Dean, New York College of Traditional Chinese Medicine, New York, NY, USA.
Xiuyan WangUltrasound Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Rui LinGeneral Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0002-3197-9798
Baomin ShiGeneral Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0009-0008-9042-1701

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives: Catecholamine-dependent acute obstructive suppurative cholangitis (CD-AOSC) is a severe form of cholangitis characterized by refractory hypotension. This study aimed to investigate its underlying pathogenic mechanisms. Methods: We conducted a retrospective case-control study involving 345 patients with biliary infections treated at Tongji Hospital, Tongji University, between 2012 and 2022. Patients were divided into three groups: chronic cholecystitis (CC; negative control), acute obstructive suppurative cholangitis (AOSC; positive control), and CD-AOSC (case group). Clinical and laboratory data were analyzed. Endotoxin levels in subcutaneous adipose tissue were measured, and transcriptomic analysis was performed to explore potential mechanisms. A rat model of cholangitis was used to validate findings related to hypotension in CD-AOSC. Results: Patients with CD-AOSC exhibited slower endotoxin clearance from adipose tissue (1 Conclusions: Persistent hypotension in CD-AOSC appears to result from sustained activation of the IL-18/IL-18RAP pathway, driven by prolonged endotoxin release from adipose tissue. These findings highlight the potential of "Hours Exchanged Against (severity) Loss (HEAL)" strategy, in which early modulation of endotoxin release from adipose tissue by IL-1β inhibition during the initial phase of sepsis in cholangitis may improve patient survival.

Indexed as

adipose tissuecatecholamine-dependent acute obstructive suppurative cholangitisendotoxin reservoirinterleukin-1βlong-term hypotension

Identifiers

PMID41438472
PMCPMC12721365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.