ArticleJournal of translational internal medicine2025
Association between falls and dementia risk: Evidence from three cohort studies.
Article in Journal of translational internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: The relationship between falls and dementia risk remains unclear. This study aims to investigate this association and assess the impact of genetic risk on this relationship. Methods: We included 265,416, 5,506, and 948 participants from the United Kingdom (UK) Biobank, China Health and Retirement Longitudinal Study (CHARLS), and Xuanwu cognitive cohort. A Cox model and logistic regression analysis were used to estimate the relationship between falls and dementia risk. Results: Falls showed significant associations with an elevated risk of dementia in both UK Biobank (single falls: Hazard Ratio [HR] 1.22, 95% Confidence Interval [CI]: 1.13-1.31; multiple falls: HR 1.73, 95% CI: 1.58-1.89), CHARLS cohorts (falls: HR 1.29, 95% CI: 1.11-1.50) and Xuanwu cognitive cohort (single falls: OR 1.72, 95% CI: 1.18-2.50; multiple falls: OR 1.89, 95% CI: 1.17-3.02). In addition, the results showed that falls were associated with cognitive decline during follow-up. Those who experienced single falls demonstrated reduced whole-brain gray matter volume (β = -1276.031, Conclusions: Falls are an early sign of dementia risk, and genetic susceptibility facilitates this association. Falls indicate potential atrophy in cognition-related brain regions. Falls are a simple and easily observable sign for dementia screening.
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