Evidence map›Paper›PMID 41438465›Full record

ArticleJournal of translational internal medicine2025

Glue ablation therapy for patients with great saphenous vein varicosities: A randomized, parallel-controlled, multicenter, non-inferiority trial.

Kangkang Zhi, Sili Zou, Yi Hong, Lianrui Guo, Yixia Qi, Lei Zhang, Junlu Peng, Bo Ye, Guofu Zheng, Bin Hao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kangkang ZhiVascular Surgery Department, Changzheng Hospital, Naval Medical University, Shanghai, China.
Sili ZouVascular Surgery Department, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yi HongVascular Surgery Department, Shanghai East Hospital, Tongji University, Shanghai, China.
Lianrui GuoVascular Surgery Department, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yixia QiVascular Surgery Department, Xuanwu Hospital, Capital Medical University, Beijing, China.
Lei ZhangVascular Surgery Department, the First Hospital of Hebei Medical University, Hebei Province, China.
Junlu PengVascular Surgery Department, the First Hospital of Hebei Medical University, Hebei Province, China.
Bo YeGanzhou People's Hospital, Jiangxi Province, China.
Guofu ZhengGanzhou People's Hospital, Jiangxi Province, China.
Bin HaoShanxi Dayi Hospital, Shanxi Province, China.
Huimin XuShanxi Dayi Hospital, Shanxi Province, China.
Bin ChenThe Second Affiliated Hospital, Zhejiang University, Zhejiang Province, China.
Yifeng PanThe Second Affiliated Hospital, Zhejiang University, Zhejiang Province, China.
Yuefeng ZhuThe Fourth Affiliated Hospital, Zhejiang University, Zhejiang Province, China.
Jinjin WuThe Fourth Affiliated Hospital, Zhejiang University, Zhejiang Province, China.
Xiaojin HuangZhongshan Hospital, Xiamen University, Fujian Province, China.
Shenci WenZhongshan Hospital, Xiamen University, Fujian Province, China.
Xiang WangVascular Surgery Department, Shanghai East Hospital, Tongji University, Shanghai, China.
Lefeng QuVascular Surgery Department, Changzheng Hospital, Naval Medical University, Shanghai, China.ORCID https://orcid.org/0009-0001-6145-0043

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Treatment for varicose veins has transitioned from invasive surgical interventions to minimally invasive, targeted, and personalized procedures. Limited data exist on the longterm outcomes of glue ablation (GA) as a new minimally invasive treatment. This study was conducted to evaluate the long-term safety and efficacy of GA for varicose veins. Methods: Data were collected in a multicenter, prospective registry. Patients were randomly allocated to the experimental group (GA) or the control group (radiofrequency ablation [RFA]). The follow-up assessments were conducted at 7 days, 30 days, 3 months, 6 months, and 12 months after surgery. The non-inferiority of GA to RFA was assessed based on the primary outcome of the rate of complete great saphenous vein (GSV) closure at 3 months. Additional outcomes included the rate of complete GSV closure at 12 months, procedural duration, pain score, ecchymosis, and preoperative and postoperative Venous Clinical Severity Score and Aberdeen Varicose Vein Questionnaire Score. Results: Overall, 177 patients were treated (experimental group, Conclusion: The 3-month rate of complete GSV closure with GA was non-inferior to that with RFA in the treatment of varicosity, but the surgical duration was longer. The efficacy of GA therapy still requires validation through large-scale clinical trials with long-term follow-up periods.

Indexed as

glue ablationgreat saphenous vein varicositiesradiofrequency ablation

Identifiers

PMID41438465
PMCPMC12721361

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.