ReviewJournal of conservative dentistry and endodontics2025
Effect of guided tissue regeneration on the outcome of surgical endodontic treatment: An umbrella review.
Review in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Regeneration with platelet-rich fibrin and simvastatin combined with bone xenograft in periapical surgery - A comparative 4-year follow-up case study.Journal of conservative dentistry and endodontics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: This umbrella review and network meta-analysis (NMA) evaluated the comparative effectiveness of guided tissue regeneration (GTR) techniques and biomaterials in improving clinical and radiographic outcomes following surgical endodontic treatment. Methods: A systematic search of PubMed, Scopus, Embase, and Web of Science up to July 2025 identified systematic reviews and meta-analyses assessing GTR interventions. Eligible reviews included primary studies comparing resorbable and nonresorbable membranes, bone grafts, and autologous platelet concentrates. Data were extracted at the primary study level and synthesized using a frequentist random-effects NMA model. Comparative rankings were assessed using Surface Under the Cumulative Ranking (SUCRA) curves. Risk of bias was evaluated with risk of bias in systematic reviews, and credibility of evidence was assessed using a seven-domain framework. Results: Fourteen systematic reviews encompassing 48 unique primary studies were included. The combination of expanded polytetrafluoroethylene (e-PTFE) membranes with hydroxyapatite ranked highest (SUCRA = 84.4%) and showed significantly greater clinical success compared with control (odds ratio = 0.13; 95% confidence interval: 0.02-0.98). Other high-ranking strategies included concentrated growth factor plus xenogenic Bio-Oss collagen (SUCRA = 73.2%) and collagen membranes combined with bovine-derived hydroxyapatite (SUCRA = 70.8%). Overall, combination therapies consistently outperformed single-component interventions. The network demonstrated low inconsistency and minimal publication bias. However, the credibility of effect estimates was limited, with most comparisons graded as weak evidence (Class IV). Conclusion: Combination strategies incorporating barrier membranes and bone grafts, particularly e-PTFE with hydroxyapatite, appear most effective in enhancing endodontic surgical outcomes.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.