ArticleJournal of conservative dentistry and endodontics2025
Application of titanium-platelet-rich fibrin (T-PRF) in the surgical management of a periapical lesion: A report of two cases.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Clinical Outcomes of Platelet-Rich Fibrin in Endodontic Microsurgery: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Article
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Authors and funding
5 authors.
Funding
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Abstract
The primary goal of endodontic therapy is to eliminate infection and promote regeneration of periapical tissues. In cases of persistent pathology, periapical surgery combined with regenerative adjuncts may enhance healing. Titanium-prepared platelet-rich fibrin (T-PRF) provides a dense fibrin scaffold, sustained release of growth factors, and improved mechanical stability compared to conventional platelet-rich fibrin. Two young patients with trauma-induced periapical lesions in the maxillary anterior teeth underwent periapical surgery with root-end resection, retrograde mineral trioxide aggregate filling, and placement of autologous T-PRF membranes in the osseous defect. Both patients demonstrated uneventful healing, early resolution of symptoms, and progressive radiographic bone fill at 3, 6, and 12 months postoperatively. T-PRF appears to be a predictable and cost-effective adjunct to periapical surgery, promoting both soft tissue and bone regeneration.
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