Evidence map›Paper›PMID 41438438›Full record

ArticleJournal of conservative dentistry and endodontics2025

V Swetha Geervani, Kiran Kumar Neelakantappa, Seema Merwade, R S Mohan Kumar, M Abhishek, M Manimozhi

Abstract read
In one paragraph

Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Sessile growth on human dentine is associated withJournal of conservative dentistry and endodontics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

V Swetha GeervaniDepartment of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
Kiran Kumar NeelakantappaDepartment of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
Seema MerwadeDepartment of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
R S Mohan KumarDepartment of Conservative Dentistry and Endodontics, Priyadarshini Dental College, Chennai, Tamil Nadu, India.
M AbhishekDepartment of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bengaluru, Karnataka, India.
M ManimozhiDepartment of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bengaluru, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objective: The objective of this study was to systematically review Methods: A comprehensive literature search (PROSPERO CRD42024610795) was conducted using PubMed, Google Scholar, and the Cochrane Library. Studies employing computer-aided drug design methods for Results: Eleven studies met the inclusion criteria. Key protein targets included Sortase A, MurA, cyclic di-AMP synthetase, and quorum-sensing regulators. Promising inhibitors such as pinocembrin, 24-propylcholesterol, and embelin were identified, with potential to disrupt biofilm formation, quorum sensing, and bacterial metabolism. While most studies confirmed findings with Conclusion:

Indexed as

Biofilm inhibitioncomputer-aided drug designendodontic infectionsEnterococcus faecalismolecular dockingquorum sensing

Identifiers

PMID41438438
PMCPMC12721427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.