ArticleFrontiers in cell and developmental biology2025
The effect of disulfidptosis induced by glucose starvation in SLC7A11
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Beyond biochemical cascades: the biophysical execution of disulfidptosis via actin network collapse.Molecular biology reports · 2026Review
- Construction and validation of risk prediction model for glioblastoma associated with cancer stem cells and disulfidptosis.Translational cancer research · 2026Article
- Advancing the frontiers of ovarian cancer therapy: a comprehensive synthesis of emerging cell death paradigms.Oncology reviews · 2026Review
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Authors and funding
3 authors.
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Abstract
Objective: Disulfidptosis is a glucose deprivation-induced cell death mechanism driven by disulfide stress-mediated actin cytoskeleton disintegration. This study explored whether SLC7A11 Methods: Initially, we carried out an assay to assess the cell viability of IOSE 80 and OVCAR 3 cells under conditions of glucose sufficiency and starvation. Subsequently, we examined the difference in SLC7A11 expression between the two cell types under the specified conditions. The intracellular NADP Results: The results revealed that the SLC7A11 expression level in OVCAR 3 cells was higher than that in IOSE 80 cells, and OVCAR 3 cells exhibited a lower tolerance to glucose starvation. Glucose starvation stimulates SLC7A11 expression in OVCAR 3 cells, and SLC7A11 facilitates cell death in OC cells under conditions of glucose starvation. Elevated disulfide bond levels in ovarian cancer cells promote cell death under glucose starvation conditions. Conclusion: Glucose starvation induces high SLC7A11 expression in OC cells, resulting in cell death. This type of cell death is associated with NADPH depletion in the cell and the accumulation of disulfides. Therefore, it is considered that disulfidptosis may occur in SLC7A11
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