Evidence map›Paper›PMID 41438414›Full record

ArticleBiological psychiatry global open science2026

The Neurocircuitry of Cannabis Cue Reactivity in Cannabis Use Disorder: A Functional Neuroimaging Study.

Valentina Lorenzetti, Hannah Sehl, Arush Honnedevasthana Arun, Eugene McTavish, Adam Clemente, Hannah Thomson, Marianna Quinones-Valera, Alexandra Gaillard, Emillie Beyer, Diny Thomson and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Valentina LorenzettiNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Hannah SehlNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Arush Honnedevasthana ArunNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Eugene McTavishNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Adam ClementeNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Hannah ThomsonNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Marianna Quinones-ValeraNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Alexandra GaillardNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Emillie BeyerNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Diny ThomsonNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Janna CousijnNeuroscience of Addiction Laboratory, Center for Substance Use and Addiction Research, Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Izelle LabuschagneSchool of Behavioural & Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Peter RendellSchool of Behavioural & Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Gill TerrettSchool of Behavioural & Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Chao SuoNeuroscience of Addiction and Mental Health Program, Healthy Brain and Mind Research Centre, School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia.
Lisa-Marie GreenwoodSchool of Medicine and Psychology, Australian National University College of Health and Medicine, Australian National University, Canberra, Australia.
Victoria ManningMonash Addiction Research Centre, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.
Govinda PoudelMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A common feature of cannabis use disorder (CUD) is an intense reactivity to cannabis cues, which are becoming increasingly visible due to the growth in its decriminalization, accessibility, and marketing of cannabis products. The brain's automatic reactivity to cannabis cues can trigger craving and subsequent use. In this study, we aimed to test neural activity during cannabis cue reactivity in non-treatment-seeking individuals with moderate-to-severe CUD and past attempts to cut down/quit. Methods: The study examined 65 individuals with moderate-to-severe CUD and 43 control participants, with a functional magnetic resonance imaging cannabis cue-reactivity task and assessment of mental health and substance use as well as cognitive testing. Group differences in neural responses to cannabis cue reactivity were examined, adjusting for age and sex; correlations with cannabis use characteristics and mental health variables were assessed, accounting for recent substance use. Results: Compared with control participants, individuals with CUD showed greater brain activity during cannabis cue reactivity in the superior/middle occipital, medial/lateral orbitofrontal cortex, anterior/posterior cingulate, cerebellar, hippocampus, and middle temporal and lateral parietal cortices ( Conclusions: Exposure to cannabis cues can elicit greater activity within salience evaluation/attention, motivation, and disinhibition pathways of addiction neurocircuitry in people with moderate-to-severe CUD, consistent with prominent neuroscientific theories of addiction and findings with other substances. Interventions that can suppress brain activity in salience and attention circuits during cannabis cue reactivity may help reduce craving and subsequent use.

Indexed as

CannabisCannabis use disorderCravingCue reactivityfMRINeuroimaging

Identifiers

PMID41438414
PMCPMC12720038

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.