Evidence map›Paper›PMID 41438382›Full record

ArticleJournal of pain research2025

LncRNA-Associated ceRNA Network in the Spinal Cord Reveals the Central Mechanism of Chronic Inflammatory Visceral Pain.

Xiaoying Li, Xuejun Wang, Xiaoqing Dong, Zhiyuan Li, Yunqiong Lu, Li Liu, Guang Yang, Jue Hong, Yanting Yang, Cuihong Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaoying Li *Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Xuejun Wang *Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China.
Xiaoqing Dong *Department of Acupuncture and Moxibustion, Xi'an Traditional Chinese Medicine Hospital of Encephalopathy, Xi'an, People's Republic of China.
Zhiyuan Li *Department of Acupuncture and Moxibustion, Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen, People's Republic of China.
Yunqiong LuYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Li LiuYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Guang YangLaboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, People's Republic of China.
Jue HongLaboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, People's Republic of China.ORCID 0000-0002-9857-818X
Yanting YangLaboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, People's Republic of China.ORCID 0000-0003-1388-4047
Cuihong ZhangLaboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, People's Republic of China.
Huangan WuYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.ORCID 0000-0003-1725-6881
Dan ZhangLaboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, People's Republic of China.ORCID 0000-0003-0747-8691
Xiaopeng MaYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To study and analyze the varieties across long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs in spinal cord, construct the competing endogenous RNAs (ceRNAs) network, and discuss the possible central mechanism in the development of chronic inflammatory visceral pain (CIVP). Methods: The colitis-associated CIVP rat model was prepared using 2,4,6-trinitrobenzene sulfonic acid (TNBS) enema. The abdominal withdrawal reflex (AWR), mechanical withdrawal threshold (MWT), and thermal withdrawal latency (TWL) were used to evaluate the rat's pain behaviors. The whole transcriptome sequencing technique was adopted to analyze the differentially expressed lncRNAs, miRNAs, and mRNAs in the spinal cord. LncRNA-associated ceRNA network was constructed and identified using the ceRNA MuTATE method and the hypergeometric distribution algorithm. The sequencing result was then verified using the quantitative real-time PCR (RT-qPCR). Results: Compared to the normal group, CIVP rat models had significantly increased AWR and decreased MWT and TWL (all Conclusion: LncRNA TCONS_00001477 and TCONS_00019815 may regulate Col2a1 and Hoxd10 mRNAs by competitively binding to miR-3120, miR-542-5p, and miR-450b-3p, thereby participating in colitis associated CIVP.

Indexed as

central mechanismceRNA networkcolitislncRNAvisceral pain

Identifiers

PMID41438382
PMCPMC12719633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.