Evidence map›Paper›PMID 41438381›Full record

ArticleFrontiers in microbiology2025

Spatial microbiome-metabolic crosstalk drives CD8

Xiaoyang Chen, Yinxu Zhang, Guangyu Zhang, Dai Wang, Linhua Dou, Yuxi Wang, Zining Huang, Xiaomei Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Programming the tumor microenvironment through microbiome-driven mechanisms.Frontiers in cellular and infection microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoyang Chen *Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Yinxu Zhang *Department of Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Guangyu Zhang *Department of Anesthesiology, Medical College of Jinzhou Medical University, Jinzhou, Liaoning, China.
Dai WangDepartment of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Linhua DouDepartment of Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Yuxi WangDepartment of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.
Zining HuangHuashan School of Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Xiaomei LiuDepartment of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The spatial organization of intratumoral microbiota and its metabolic impact on immunotherapy response in colorectal cancer (CRC) is unclear, limiting targeted interventions. Methods: We integrated single-cell RNA-seq, spatial transcriptomics, and microbial multi-omics from a discovery cohort of 23 treatment-naïve CRC patients. Findings were validated in an independent validation cohort from The Cancer Genome Atlas (TCGA-CRC, Results: Spatial depletion of Conclusion: Our study unveils a spatially defined, microbiome-driven metabolic niche that epigenetically programs CD8

Indexed as

butyrate metabolismCD8+ T-cell exhaustioncolorectal cancerHDAC inhibitionmicrobiome-metabolic-immune crosstalkspatial microbiome

Identifiers

PMID41438381
PMCPMC12719255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.