Evidence map›Paper›PMID 41438363›Full record

ArticleOpen respiratory archives

Predictors of Progression in Pre-COPD: The 3P Study Rationale and Design.

Cruz González-Villaescusa, Julia Tarrasó Castillo, Dolores Martínez-Pitarch, Juan A Riesco Miranda, Elena García-Castillo, Carolina Gotera Rivera, Laura Carrasco Hernández, Patricia Sobradillo Ecenarro, Jaime Signes-Costa, Elsa Naval Sendra and 8 more

Abstract read
In one paragraph

Article in Open respiratory archives. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Small Airway Disease in Pre-COPD and Early COPD: Insights Into the Pulmonary "Silent Zone".International journal of chronic obstructive pulmonary disease · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Cruz González-VillaescusaServicio de Neumología, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Julia Tarrasó CastilloInstituto de Investigación Sanitaria INCLIVA, Valencia, Spain.
Dolores Martínez-PitarchServicio de Neumología, Hospital Lluís Alcanyís, Xátiva, Spain.
Juan A Riesco MirandaServicio de Neumología, Hospital Universitario de Cáceres, Cáceres, Spain.
Elena García-CastilloServicio de Neumología, Hospital de La Princesa, Madrid, Spain.
Carolina Gotera RiveraServicio de Neumología, Hospital Universitario Fundación Jiménez - Díaz, Madrid, Spain.
Laura Carrasco HernándezServicio de Neumología, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Patricia Sobradillo EcenarroServicio de Neumología, Hospital Universitario de Cruces, Baracaldo, Spain.
Jaime Signes-CostaServicio de Neumología, Hospital Clínico Universitario de Valencia, Valencia, Spain.
Elsa Naval SendraServicio de Neumología, Hospital Universitario de la Ribera, Alzira, Spain.
Francisco Javier Callejas GonzálezServicio de Neumología, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
Andrea Yordi LeónServicio de Neumología, Hospital Universitario Infanta Elena, Madrid, Spain.
Laura Vigil GimenezServicio de Neumología, Parc Taulí Hospital Universitari, Barcelona, Spain.
Marta Núñez FernándezServicio de Neumología, Complejo Hospitalario Universitario de Vigo, Vigo, Spain.
Marta Palop CerveraServicio de Neumología, Hospital de Sagunto, Sagunto, Spain.
Juan A Carbonell-AsinsBioinformatics and Biostatistics Unit, INCLIVA, Valencia, Spain.
Alvar AgustiCatedra Salud Respiratoria, University of Barcelona, Spain.
Field Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The diagnosis of chronic obstructive pulmonary disease (COPD) requires the demonstration of poorly reversible airflow obstruction (defined by a forced expiratory volume in 1 s [FEV Material and methods: This will be a prospective (5-year follow-up), multicenter (conducted in 12 Spanish centers across eight geographical autonomous communities), observational, comparative study (www.clinicaltrials.govNCT04409275), that will recruit 285 current or former smokers (≥10 pack-years) with respiratory symptoms (dyspnea, chronic cough, sputum production, wheezing or recurrent lower respiratory tract infections) and spirometry without obstruction (pre-COPD status). Multivariate regression analysis and other tests will be used to analyze results. Conclusion: Results are expected to provide novel, useful information for identifying pre-COPD individuals who are likely to develop progressive airflow obstruction and are potential candidates for prompt intervention.

Indexed as

BiomarkerChronic bronchitisEmphysemaPre-COPDSmokingSpirometry

Identifiers

PMID41438363
PMCPMC12721031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.