Evidence map›Paper›PMID 41438225›Full record

ArticleJournal of orthopaedics2026

Objective selection of bone mimetic materials using impact microindentation.

Lucas R Budd, Rachana S Vaidya, Babak Jahani, Saideep Nakka, Alexander Proctor, Peter T Burks, Blake K Montgomery, Simon Y Tang

Abstract read
In one paragraph

Article in Journal of orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Lucas R BuddDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, MO, 63110, USA.
Rachana S VaidyaDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, MO, 63110, USA.
Babak JahaniDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, MO, 63110, USA.
Saideep NakkaMedtronic Inc. 4620 N Beach St, Fort Worth, TX, 76137, USA.
Alexander ProctorActive Life Scientific, Inc, Santa Barbara, CA, USA.
Peter T BurksActive Life Scientific, Inc, Santa Barbara, CA, USA.
Blake K MontgomeryDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, MO, 63110, USA.
Simon Y TangDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, MO, 63110, USA.

Funding

Measuring Whole and Tissue Level Bone Strength in menR44AG071034 · NIA · ACTIVE LIFE SCIENTIFIC, INC. · PI BURKS, PETER, TANG, SIMON YUE-CHEONG · 2021 to 2025
$5.2M
NIA NIH HHS R44 AG071034
6 · The paper itself

Abstract

Background: Research and development for orthopedic medical devices, implants, surgical technique, and surgical education all require the appropriate selection of bone mimetic materials to align with the physiologic conditions. There is a critical need for an objective measure of material strength that can be collected, practically, on both bone mimetic materials and living human bone to improve mimetic material selection. Methods: This study stratifies commonly used synthetic materials in orthopedic research, as well as animal and human bone, using impact microindentation. The impact microindentation is performed with the OsteoProbe, an FDA-approved handheld medical device that can quantify material strength via the Bone Material Strength index in living human bone and mimetic materials non-destructively and in situ. Categories of Low, Mid, and High are created in reference to published living human tibia Bone Material Strength index ranges. All materials tested are classified into these categories for streamlined bone mimetic material selection. Results: Nine mimetic materials fell within the Low category. Two mimetic materials were classified as Mid and two as High. The male human cadaver cranium, radius, and femur fell within the High category; the male spine was classified in the Mid hardness category. In female cadaver tissue, the spine corresponded to the Low hardness category, the radius to Mid, and the femur to High. The ovine skull fell within the Mid category. Both the porcine thoracolumbar spine and bovine scapula fell within the High category. Conclusion: This unified scale of material strength allows for the comparison of human bones, animal bones and synthetic materials. By stratifying bone mimetics into three categories (Low, Mid, and High) of material strength based on healthy reference interval of living human Bone Material Strength index values, this study introduces a simplified framework to guide targeted material selection in orthopedic research and surgical training.

Indexed as

Bone hardnessBone mimetic selectionImpact microindentationImplant testingSurgical training

Identifiers

PMID41438225
PMCPMC12720120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.