Evidence map›Paper›PMID 41438207›Full record

ArticlemicroLife2025

Glucose metabolism controls oxidative burst and lipid mediator production in neutrophils upon microbial challenge.

Alexandra Freitag, Kerstin Günther, Miriam Campillo Prados, Sophia M Hochrein, Werner Schmitz, Katrin Sinning, Gunther Zischinsky, Bert Klebl, Knut Ohlsen, Joachim Morschhäuser and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandra FreitagWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians University of Würzburg, 97078 Würzburg, Germany.ORCID https://orcid.org/0009-0000-5253-1784
Kerstin GüntherDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, 07743 Jena, Germany.
Miriam Campillo PradosWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians University of Würzburg, 97078 Würzburg, Germany.
Sophia M HochreinWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians University of Würzburg, 97078 Würzburg, Germany.
Werner SchmitzDepartment of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, Julius-Maximilians University of Würzburg, 97074 Würzburg, Germany.ORCID https://orcid.org/0000-0003-0485-7303
Katrin SinningWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians University of Würzburg, 97078 Würzburg, Germany.ORCID https://orcid.org/0009-0004-5841-2398
Gunther ZischinskyLead Discovery Center GmbH, 44227 Dortmund, Germany.
Bert KleblLead Discovery Center GmbH, 44227 Dortmund, Germany.
Knut OhlsenInstitute of Molecular Infection Biology, University of Würzburg, 97080 Würzburg, Germany.
Joachim MorschhäuserInstitute of Molecular Infection Biology, University of Würzburg, 97080 Würzburg, Germany.
Oliver WerzDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, 07743 Jena, Germany.
Paul M JordanDepartment of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University, 07743 Jena, Germany.
Martin VaethWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians University of Würzburg, 97078 Würzburg, Germany.ORCID https://orcid.org/0000-0001-8974-7052

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils are frontline responders against bacterial and fungal pathogens, requiring rapid energy and biosynthetic precursors to mount effective antimicrobial responses. To meet these demands, they primarily rely on aerobic glycolysis, making glucose uptake essential. Murine and human neutrophils express the glucose transporters GLUT1 and GLUT3; however, their specific roles in neutrophil immunobiology have not yet been fully elucidated. Here, we show that neutrophilic immune responses to

Indexed as

GLUT1GLUT3glycolysisimmunometabolismneutrophils

Identifiers

PMID41438207
PMCPMC12721385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.