Evidence map›Paper›PMID 41438205›Full record

ArticleBioactive materials2026

Additively manufactured Tantalum-titanium alloys with optimized osteogenic and immunomodulatory properties for load-bearing orthopedic implants.

Junlei Li, Fang Cao, Xiaoyan Chen, Yada Li, Guangxiao Yin, Pinqiao Yi, Liqun Song, Jiahui Yang, Zhihua Cheng, Jiawei Ying and 4 more

Abstract read
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Near-Infrared-Induced Hydrophobic Characteristic of Black TiOJournal of functional biomaterials · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junlei LiDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Fang CaoDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Xiaoyan ChenDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Yada LiDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Guangxiao YinDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Pinqiao YiDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Liqun SongDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Jiahui YangDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Zhihua ChengDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Jiawei YingDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Liangliang ChengDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Simiao TianDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Xiuzhi ZhangDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Dewei ZhaoDepartment of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Tantalum-Titanium (TaTi) alloys demonstrate significant potential as an orthopedic implant material. This study presents the development and comprehensive evaluation of novel additive manufactured TaTi alloys for orthopedic implant applications. Through a combination of materials engineering and biological validation, we designed pre-alloyed TaTi spherical powders with varying compositions (Ta25, Ta55, and Ta75) and fabricated dense and porous structures via selective laser melting (SLM). The SLM Ta55 alloy (Ti-55 wt %Ta) exhibited optimal mechanical properties, including a tensile strength of 891 MPa and an elastic modulus of 74 GPa, closely matching cortical bone. Surface characterization revealed that oxide layer (comprising Ta

Indexed as

ImmunomodulationOrthopedic implant materialOsteogenesisSelective laser melting (SLM)Tantalum-titanium (TaTi) alloys

Identifiers

PMID41438205
PMCPMC12720114

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.