ArticleBioactive materials2026
Glutathione peroxidase mimic-engineered α-lactalbumin self-assembling coatings tailor immunomodulatory vascular stents for suppressing restenosis.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Timely endothelial regeneration and repair after stenting is essential for enhancing vascular healing performance. This necessitates that the stent surface be capable of maintaining a positive balance or sequential regulation among thrombosis, inflammation, and the growth behavior of smooth muscle cells (SMCs) and endothelial cells (ECs); however, a key challenge in achieving this goal remains. Herein, we report an immunomodulatory glutathione peroxidase (GPx) mimic-engineered α-lactalbumin self-assembling coating (LASC) for tailoring such surface multi-functionalities of a stent. The coating is achieved by first pre-coating an α-lactalbumin self-assembling nano-film driven by an oxidizing agent onto the stent surface, followed by covalent immobilization of GPx mimics (i.e., Cu
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