Evidence map›Paper›PMID 41438203›Full record

ArticleBioactive materials2026

Immunoregulatory protein-hybrid extracellular vesicles via self-loadable backbone cyclization for oral inflammatory bowel disease therapy.

Yeonju Lee, Chaerim Yoo, Kyung-Min Kim, Sumin Kim, Yu Kyung Oh, Sookyung Cho, Gil-Ran Kim, Je-Min Choi, Ji Yeong Yang, Hyo-Il Jung and 3 more

Abstract read
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In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yeonju LeeDepartment of Life Science, Hanyang University, Seoul, 04763, Republic of Korea.
Chaerim YooDepartment of Bioengineering, Hanyang University, Seoul, 04763, Republic of Korea.
Kyung-Min KimDepartment of Life Science, Hanyang University, Seoul, 04763, Republic of Korea.
Sumin KimDepartment of Life Science, Hanyang University, Seoul, 04763, Republic of Korea.
Yu Kyung OhDepartment of Bioengineering, Hanyang University, Seoul, 04763, Republic of Korea.
Sookyung ChoDepartment of Life Science, Hanyang University, Seoul, 04763, Republic of Korea.
Gil-Ran KimDepartment of Life Science, Hanyang University, Seoul, 04763, Republic of Korea.
Je-Min ChoiDepartment of Life Science, Hanyang University, Seoul, 04763, Republic of Korea.
Ji Yeong YangSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Hyo-Il JungSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Sijin ParkElixir Pharmatech Inc., Seoul, 07463, Republic of Korea.
Dong Yun LeeDepartment of Bioengineering, Hanyang University, Seoul, 04763, Republic of Korea.
Young-Pil KimDepartment of Life Science, Hanyang University, Seoul, 04763, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the potential of extracellular vesicles (EVs) and therapeutic proteins as carriers and cargos for oral delivery, their precise functional integration remains a persistent challenge, thereby limiting synergistic therapeutic outcomes. Here, we present a protein-hybrid, orally delivered EV strategy that integrates naturally bioactive EVs with self-loadable, backbone-cyclized immunoregulatory proteins for inflammatory bowel disease (IBD) therapy. Through computationally guided design and split intein-mediated backbone cyclization, we generated cyclized variants of key immunoregulatory proteins with improved functionality. Among these, C-R

Indexed as

Anti-inflammationExtracellular vesicleInflammatory bowel diseaseOral deliveryProtein cyclizationT-cell protein tyrosine phosphatase

Identifiers

PMID41438203
PMCPMC12720103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.